In May 1897, natives in Transylvania seem afraid when they learn solicitor Jonathan Harker is going to Castle Dracula. Jonathan finds Count Dracula abrupt and impatient to get things done. Dracula reacts very strongly to a photograph of Harker's fiancée Mina Murray and her best friend, Lucy Westenra. After preventing his brides from devouring Harker, he forces the young solicitor to write a letter saying he will be staying in Transylvania for a month. Harker climbs down the castle wall and finds Dracula's coffin but is attacked and knocked out by one of Dracula's gypsy servants before he can stake Dracula. They later throw him in the lower levels of the crypt, where the brides attack him again.
The ship the Demeter runs aground carrying only Dracula and the dead captain lashed to the wheel. Soon after, Lucy begins to fall ill. Her fiancé, Arthur Holmwood, is perplexed and calls in Dr. Abraham Van Helsing. Dracula arrives at the house in Hillingham and uses remote hypnosis to make the occupants fall asleep, he then turns his attention to Lucy. Entranced, Lucy awakes in a highly aroused state and, sensing Dracula's presence, is drawn outside to him and completely spellbound. After a brief and passionate seduction she is fully pliant and completely under his will and consumed by bloodlust, Dracula bites on Lucy's neck and feeds on her blood as she is in a helpless state of bliss. Van Helsing starts to recognize what might be happening, after Lucy is found, drained of blood, under a tree the next morning. Dracula has flashbacks of his wife Maria – of whom Lucy is the spitting image – on her deathbed centuries earlier.
Lucy's mother Mrs. Westenra is in the room with Arthur when Dracula comes calling the last time, a wolf shattering the window and attacking Arthur. Lucy soon rises from the dead and comes to the window of Arthur's home, begging to be let in. Arthur does so, delighted and amazed that she's alive, unaware that she is now a vampire under Dracula's control. This very nearly gets him bitten, but Van Helsing interrupts with a cross causing her to flee. They go to Lucy's grave and drive a wooden stake into her heart. When Dracula comes to the tomb later and beckons to her, he goes berserk upon finding that she's truly dead.
Mina tells Van Helsing about the news story about the Demeter, the boxes of earth, and Jonathan going to meet Dracula to sell him a house. From these clues, Van Helsing and Holmwood go about finding all but one of Dracula's "boxes of earth" (containing his native soil, in which a vampire must rest). But back at the hotel, the vampire hunters discover Dracula is there seeking revenge. He has bitten Mina and, before their eyes, forces her to drink blood from a self-inflicted gash in his chest.
The tracking of Dracula back to his home commences with Van Helsing hypnotizing Mina. Via the bond of blood, she sees through Dracula's eyes and discovers where he is headed. At the castle, Van Helsing and Holmwood find and stake the brides. Jonathan, now a rabid and bloodthirsty vampire, attacks Arthur and Van Helsing, but in the struggle is knocked by Arthur into a pit of spikes and killed. The final confrontation with Dracula takes place in what looks like a grand ballroom. Arthur produces a cross, temporarily keeping Dracula at bay, but the vampire throws a table at them, knocking it away. As Dracula attacks Arthur, Van Helsing pulls down the window curtains, and sunlight pours in. Dracula is weakened, giving Van Helsing the opportunity to pierce his heart with a long spear.
They leave him there. Before the portrait of a living warrior Dracula, with Lucy's past self Maria in the background, a text scrolls across the screen about a warlord Vlad the Impaler who lived in the area of Romania known as Transylvania, and how it was said he had found a way to conquer death – a legend no one has ever disproven.
Dracula is confronted by Van Helsing and Holmwood in his castle. After the brides are slain and Jonathan (now a vampire) is killed, a final showdown ends with Dracula facing the vampire hunters.
The ending brings the gothic pursuit full circle, as Dracula’s centuries-old longing leads to his downfall at the hands of those he sought to torment. The destruction of his brides and Jonathan’s tragic fate underscore the consequences of Dracula’s obsession. The clash in the castle ballroom, with symbols of faith prevailing, reiterates the classic battle between good and evil, while highlighting the tragic undertones of Dracula’s character.