Six friends, Christian, David, Kate, Johnny, Sara, and Melody, are traveling in an RV to get to the wedding of their friend, Kelly, in Galveston, Texas. However they become lost in a small town called Lovelock, and decide to spend the night at the local bed and breakfast, owned by the creepy Mr. Wise. While staying, the group insult the chef, Henri, causing an argument to break out. After everyone goes to bed, David goes to the kitchen to get a snack, only to discover Henri brutally murdered, before Mr. Wise suffers a heart attack.
With the phone line broken, it takes until morning for the sheriff, and his deputy, Enus, to be summoned for help. The sheriff is quick to suspect the group, and takes the keys to the RV away, so they can not leave the town until the investigation is over. The group goes into town, while the sheriff arrests a mysterious drifter, who quickly becomes the prime suspect. The drifter warns Christian and Sara of ancient exotic wooden box, that Sara realizes belongs to Mr. Wise. However it is too late, as Johnny arrives back at the bed and breakfast and opens the box, unleashing the "Kuman Thong" which possesses him, causing him to savagely murder various people. Meanwhile, Christian and Sara meet town local Lisa Belmont who swears she saw Mr. Wise dig up the body of his dead son and perform a form of black magic on the body. Sara and Christian return to the bed and breakfast and discover Johnny has opened the box.
Sara and Christian alert the sheriff, who drives them to a local party, that David, Kate and Melody are attending with the rest of the town folk. The possessed Johnny arrives and a bloody massacre ensues, with the town folk, including Enus, becoming zombies as Johnny puts various body parts of his victims in the box. In the chaos, Christian is decapitated as David, Kate, Sara and Melody escape with the sheriff in a truck. They accidentally run over the drifter, knocking him unconscious after he escapes from his prison cell. Taking him with them, the radiator soon blows in the truck, forcing the group to take shelter in the bed and breakfast. They gather weapons, before the drifter tells them they must retrieve the body of Mr. Wise to kill Johnny. The zombies arrive at the bed and breakfast and the group fend them off, before the sheriff, Melody and the drifter sneak out the back door to retrieve the bones of Mr. Wise.
At the bed and breakfast, the zombies retrieve some of David's blood that was on the step of the house, placing it in the box causing him to become possessed. David beats Kate to death with a metal pole, before attacking Sara. However Sara manages to kill David with a chainsaw. At the cemetery, the sheriff, Melody and the drifter retrieve the body of Mr. Wise and perform a black magic spell, taking the bones from the body. As they travel to the bed and breakfast they encounter a group of zombies. The sheriff has his neck snapped, killing him, before Lisa arrives and rescues the drifter and Melody, who continue on to the bed and breakfast. Meanwhile, at the bed and breakfast, the zombies break in. Sara fights them, but is soon cornered. The drifter, and Melody arrive outside, where Melody shoots Johnny through the heart with a bone from the body of Mr. Wise, killing him and the other zombies. Sara reunites with Melody and the drifter, and together they leave Lovelock in their RV
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