Professor Frankenstein (Whit Bissell), a guest lecturer from England, talks Dr. Karlton (Robert Burton) into becoming an unwilling accomplice in his secret plan to actually assemble a human being from the parts of different cadavers. After recovering a body from a catastrophic automobile wreck, Professor Frankenstein takes the body to his laboratory/morgue, where he keeps spare parts of human beings in various drawers. The professor also enlists the aid of Margaret (Phyllis Coates), as his secretary, to keep all callers away from the laboratory.
Margaret, becoming suspicious of what is going on, decides to investigate and goes down to the morgue. She is panic-stricken by the monster (Gary Conway), who has been activated following the grafting of a new leg and arm. She dares not tell the professor about her feelings and keeps silent for the present. On a couple of occasions, the professor takes discarded human body parts...and feeds them to an alligator concealed in a hidden chamber.
One night, the monster leaves the laboratory. He peers into a girl's apartment. The girl becomes hysterical and starts screaming; in his attempt to silence her, he kills her in panic and flees. The next morning, the hunt for the murderer is on. Margaret, angry at the professor, tells him that she knows that the monster is responsible for the murder. The professor, taking no chances, has the monster kill her and feeds her remains to the alligator. Dr. Karlton, sent out of town, knows nothing about this.
The professor accompanies the monster to a lover's lane, where he kills a teenage boy in order to obtain his face. The boy's face is successfully grafted onto the monster. Professor Frankenstein tells Dr. Karlton of his plans to dismember his creation and ship him in various boxes to England and then return there to put him together again. When they strap the monster down again, he becomes suspicious and tears loose — to throw Professor Frankenstein into the alligator pit — while Dr. Karlton runs for help.
When Dr. Karlton arrives with the police, the monster, maddened with fright, backs into the electrical dial board. Contact with the iron wrist bands electrocutes him and he falls to the ground, dead. Karlton tells the police that he will never forget the way the monster's face looked after the accident.
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