Vince Raven (Cooper) is performing in the music video for his new song, "Identity Crisis." Later, Vince, Vince's girlfriend Sandra, and Vince's film crew drive to Vince's old childhood home to shoot a music video.
While waiting for the crew, Jos, the caretaker of the house, prepares a welcome home party for Vince. He is interrupted when he begins hearing strange noises. After searching around the house, he walks outside to find a pack of wild canines growling outside his door. The canines outnumber him and attack him.
That evening the crew continue their drive to the house. Along the way, they run into two police officers, Sheriff Morrison and Deputy Dan, who are standing at a barricade. The police warn the crew that there has been another "attack". After the crew leave, the sheriff and his deputy are both killed by the Monster Dog in the woods.
The drive comes to a halt when Vince hits a German Shepherd with the van. The crew cannot stand to watch it suffer in pain, so Vince puts it to rest by killing it with a large rock. While the crew mourns the dog's death, an old man in blood-stained clothing attacks them. He warns them that they "will all die", except for Vince. The old man then runs into the woods. Vince and Sandra chase after him to get him to a hospital, but the Monster Dog scares them back into the van.
When the crew finally arrives at the house, Jos is nowhere to be found. Vince is worried about what happened to Jos, so he takes a shotgun and searches around the house. While the crew waits for Vince to return, they discover the food for the party. After searching the house, Vince gives up and wanders into a room where he discovers a book about werewolves.
Later that night Angela has a nightmare that the bloody old man murders everyone in the house. She runs from him and tries to get to Vince. She finds him reading a book in a rocking chair, his back toward her. She slowly walks up to him from behind until he gets up, revealing that he is the Monster Dog. Angela wakes up screaming and the crew tries to calm her down. She tells them about her dream and how Vince was a "werewolf".
Vince is later found reading in the same rocking chair as in Angela's nightmare. Sandra comes to talk to him, and he tells her the story of his father's death. He says that his father had lycanthropy (the werewolf curse) and that he was blamed for many deaths. He was stabbed with pitchforks, doused with gasoline, and burnt alive.
The next day, the crew decides to begin filming their next music video for Vince's song, "See Me in The Mirror". Angela is dressed as a bride and Vince sings to his reflection in a mirror. As Angela walks down the stairs, she notices the shadow of a body that is resting against the upstairs window. The light outside flashes and the body crashes through the window. It is revealed to be Jos's corpse. Angela leaves the house in shock while the others search the roof to find out what happened. Vince runs after Angela as a mysterious car pulls up to the house.
The four armed men con their way into the house and quickly overpower the crew. They wait inside until Vince and Angela return. As they try to come in, one of the men shoots and kills Angela by mistake, forcing Vince to escape.
Vince heads to the roof where he has a shootout with some of the armed men. Meanwhile, a pack of wild dogs break into the house and attack the crew and one of the armed men. Sandra and Marilou run upstairs, with the dogs chasing them while the Monster Dog appears and kills the others. Strangely the dogs become calm when Vince appears, allowing them to get to the car. Because the armed men had the keys, they have to go back and get them, leaving Marilou in the car alone.
Vince and Sandra return to the car with the keys after another run in with a gunman. As they drive off, Marilou's corpse falls on Sandra and the Monster Dog attacks Vince from the back seat. Sandra jumps out and hears the car get destroyed with the sound of a gunshot. She finds the old man, who tells her about how he was attacked by Vince's father, which resulted in him becoming a "lycanthrope". The old man dies after telling Sandra that he has bitten Vince and that Vince will now become a werewolf. Sandra leaves to find Vince, who tells her to kill him before he turns into a werewolf. As Vince begins his transformation into the Monster Dog, Sandra shoots him.
The film ends with a reprise of the "Identity Crisis" video, now interspersed with clips from the story.
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