Lifelong vegetarian Justine begins her first semester at veterinary school, the same one her older sister Alexia is attending and where their parents met. On her first night, she meets her roommate Adrien, and they are forced to partake in a week-long hazing ritual, welcoming the new students. They are brought to a party, where Alexia shows Justine old class photos of students bathed in blood, including one with their parents. The next morning, the new class is splattered with blood and are forced to eat raw rabbit kidneys. Justine refuses because of her vegetarianism, but Alexia forces her to eat one. Justine leaves with Adrien and later discovers an itchy rash all over her body. She goes to the doctor, who diagnoses her with food poisoning and gives her a cream for the rash.
The next day, Justine begins having cravings for meat, which makes her feel ashamed. She and Adrien take a late-night trip to a gas station so no one will see her eating meat. Unsatisfied, she eats raw chicken in the morning, and later throws up a long bundle of her own hair she had been chewing on. That night, Alexia attempts to gives her a bikini wax, but when Alexia tries to cut the wax off with sharp scissors, Justine kicks her away and Alexia accidentally cuts off her own finger. Alexia faints, and Justine picks up the finger, tastes the blood, and starts eating it. Alexia wakes up to find Justine doing this but later tells their parents that her dog, Quicky, ate it.
The next morning, Alexia takes Justine to a deserted road, where she jumps in front of a car, causing the two people in it to crash into a tree. Alexia starts eating one of the passengers to Justine's dismay so she would "learn". Despite this, Justine's craving for human meat grows and she starts lusting after Adrien. That night, she arrives at a party, where paint is thrown at her as part of another hazing ritual and she is forced to make out with someone. While kissing, Justine bites the middle of his bottom lip off, leaving the other party guests shocked in disgust. Justine goes back to her dorm and takes a shower, where she picks a chunk of his lip out of her teeth and eats it. Justine confides in Adrien and they end up having sex, during which Justine tries to bite Adrien but instead bites her own arm until it bleeds, seeming to orgasm while doing so.
At another party, Justine gets extremely intoxicated and Alexia takes her to the morgue. The next day, everyone in school stares at Justine, some avoiding her. Adrien shows her a video where Justine is crawling on all fours, trying to take a bite out of the arm of a corpse, which Alexia pulls out of reach with a crowd of bewildered party guests booing and watching. Justine confronts Alexia and fights her, eventually biting each other until they are pulled apart by other students. Justine helps Alexia up, and they walk each other back to their dorms. The next morning, Justine wakes up in bed with Adrien but she notices blood on her hand and pulls off the blankets, finding Adrien dead with most of his right leg eaten and a stab wound in his back. Justine then sees a bloody Alexia slumped on the floor. Justine is initially furious that Alexia killed Adrien but then cleans Alexia and herself up in the shower.
Alexia is imprisoned for the murder of Adrien, and Justine is sent back home. There, Justine's father tells her that what happened is neither her nor Alexia's fault. He explains that when he first met their mother, he could not understand why she did not want to be with him. Her father says he finally realized when they kissed the first time, indicating a scar on his lip. He then opens his shirt, revealing scars and missing chunks of his chest and tells Justine that she will find a solution.
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