Pike (Jim Brown), the right-hand man of cattle rancher Bob Morgan (Dana Andrews), is entrusted with a mission to deliver $86,000 across the border to the Morgan Ranch in Sonora, Mexico after his boss dies. Pike teams up with dishonest gambler Tyree (Fred Williamson) and they are forced to trust each other while being pursued by various outlaws and gunmen trying to possess the money, including the ruthless bounty hunter Kiefer (Lee Van Cleef) and corrupt sheriff Kane (Barry Sullivan).
Along the way, the duo comes across a prostitute (Catherine Spaak) in need of rescuing and Kashtok (Jim Kelly), a mute Indian scout skilled in martial arts, as well as Chico, an orphan Mexican boy. After numerous gun battles and chases, Pike and Tyree reach the end of the line at an abandoned mine, where they duke it out over the money, yet finally settle and work together after getting word of the approaching gunmen.
They give the money to the boy, then tell Kashtok to give safe passage to Chico and get the money safely to the ranch. Pike and Tyree devise a plan to escape by using explosives to blow up the mine shaft behind them, killing all their pursuers except for Kiefer, who decides to forgo his bounty and let the men continue their quest to reach the ranch.
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