An American couple, Dr. Shane Brown and his wife June, go to Paris, ostensibly for their honeymoon. In reality, Shane has come to Paris to hunt down neuroscientist Dr. Léo Sémeneau and his wife, Coré, whom Shane once knew and was obsessed with. Despite having had a prolific career, Léo is now working as a general practitioner to keep a low profile. He locks Coré in their house every day, but she occasionally escapes and initiates sex with men before violently murdering them. To protect her, Léo buries the bodies.
Shane begins investigating Sémeneau's whereabouts. A doctor who once worked with Léo eventually gives Shane the couple's address, explaining that Coré is unwell. Meanwhile, two young men who have been casing the Sémeneau home break in, and one of them finds Coré in a boarded-up room. After she seduces him, they begin to have sex, but she violently bites him to death, ripping out his tongue with her teeth. When Shane arrives at the house, he discovers Coré covered in blood. She tries to bite him, but Shane is able to overpower her. As he strangles her, she drops a match, setting the house on fire. Shane leaves her to be consumed by the flames. Just after Shane departs, Léo arrives and witnesses the carnage and the dead Coré.
After Coré's death, Shane becomes strange and distant. While having sex with his wife, he stops and finishes by masturbating, then runs away from her and adopts a puppy. Finally, he goes to a hotel where he brutally rapes a maid and bites her to death, then showers and washes the blood from his body. His wife enters and the couple agree to return home.
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