Cheech and Chong are driving a limo through the desert. Chong, who has decided to stop doing drugs for a while, is talking about rock and roll, and Cheech is falling asleep, but Cheech is narrating over what's happening. He says that "things are tough all over" and that he's going to tell their story.
It's an awful winter in Chicago, and Cheech and Chong are poor, struggling musicians working at a car wash owned by a pair of oil-rich Arabs, Mr. Slyman and Prince Habib. After messing up on the job, the 2 are forced by the Arabs to work and play music at their club. Cheech and Chong also try to get with the Arabs' French girlfriends, who are more in love with the stoners.
The Arabs find themselves with a large sum of illegal money, which they try to get to their other business in Las Vegas. They decide to stash all the money in the seats of a limousine. The Arabs hire the stoners to drive the limousine to Las Vegas, telling them that they're sending them on a "rock tour."
Cheech and Chong at first get gas in Chicago, but when they reveal they're strapped for cash, the man at the gas station takes a piece of the car as payment. With that idea, Cheech and Chong find themselves driving across the country, selling parts and pieces of the car for gas, food, and supplies. Soon, their car becomes a wreck and looks messed up, but Cheech and Chong continue to sell parts to get by. While out in the middle of the deserts, they decide to pick up a hitchhiker, who turns out to be none other than Donna, Cheech's girlfriend. The two decide to take Donna in their messed-up limo to the nearest gas station. However, Donna is traveling with dozens of Mexicans, so the stoners end up driving all the Mexicans and Donna to the nearest gas station. To pay for gas, Cheech and Chong give the old man that runs the place a chair from the limo—which unknown to them is stuffed with the Arab's money.
Cheech and Chong deliver the messed-up limousine to the Arabs' other oil plant in the desert, to find no one there. With no other transportation or money, Cheech and Chong set out on foot into the desert. They wander into the burning deserts, suffering the Nevada heat, and trying to get cars to stop- they remain unsuccessful. Eating peyote to survive and singing to pass the time, Cheech and Chong do their best to get through the desert, though they believe they'll die from the heat.
Back in Chicago, the Arabs find out that Cheech and Chong have delivered what remains of the car without any money in it. After deciding to kill them, the Arabs fly out to Nevada in their private plane and set out by car into the desert. The Arabs meet the old man at the gas station and learn that Cheech and Chong have been around, and set out into the deserts; their car breaks down, leaving the Arabs to wander through the Nevada deserts and get lost. Meanwhile, while walking through the desert, Cheech and Chong are picked up by the Arab's French girlfriends, who take them to an abandoned motel in the middle of the desert. The French girlfriends have sex with the stoners, and are (unknown to them) on a hidden camera film. Afterwards, the French ladies leave in their car, leaving the stoners stranded in the middle of nowhere yet again. Meanwhile, the Arabs are having the same problem, looking for Cheech and Chong in the middle of the desert, having no idea where to go.
Cheech and Chong wander through the desert again until they're picked up again, this time by comedian Rip Taylor, whose puns and props make Chong cry. The comedian drives the two into Las Vegas and drops them off at a restaurant, and has them dressed up as women to cover up their rags. Cheech and Chong start to dine at the restaurant, before the Arabs show up for dinner as well, having escaped the desert. Before they can eat, all the peyote Chong consumed begins to mess with his mind. Chong becomes emotional and confused, and when the Arabs begin to notice, the stoners try to escape. However, their wigs fall off, and the Arabs realize it's Cheech and Chong. The Arabs chase the stoners out of the restaurant and through the streets of Vegas. Cheech and Chong run into a women's-only porno theater with the murder-happy Arabs on their tail. In the theater, the Arabs see the showing of the hidden camera film of the stoners having sex with the Arabs' girlfriends. While the Arabs watch, inspired, Cheech and Chong escape. The stoners ditch the women's clothes and set out on foot to leave Las Vegas. The next day, as Cheech and Chong walk out of the city, a car pulls up, and Cheech and Chong get in, to find the Arabs and their French girlfriends. At first, Cheech and Chong are terrified and try to escape, but Mr. Slyman reveals that, instead of killing them, the Arabs have decided to cast the duo in porn films and launder the money through the enterprise.
A happy ending, with a narrating Cheech reminding us that "hey, things are tough all over."
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